于世慧

教育经历

2009-09 -2013-06   沈阳药科大学         药学院    药学学士

2013-09 -2018.06   沈阳药科大学         药学院    药剂学博士

2017.09 -2018.06    Purdue University 药学院    博士联合培养

2018.07-2020.10     Purdue University 药学院    药剂学 博士后

科研项目及成果

1.基于后发性白内障防治的金雀异黄素阳离子纳米缓释-人工晶体载药系统的构建与评价

（国家自然基金，项目编号：81100654， 2012.09-2014.12）

2.基于提高药物角膜透过性的奈帕芬胺眼部传递系统的设计与评价（2015.05-2017.07）

3.Advancing innovative therapies against pandrug-resistant Gram-negative superbugs（美国NIH 基金，项目编号：R01 AI146160， $3,247,904）

发表论文情况

1.Yu Shihui, Zhang, X., Tan, G., Tian, L., Liu, D., Liu, Y., ... & Pan, Weisan*. A novel pH-induced thermosensitive hydrogel composed of carboxymethyl chitosan and poloxamer cross-linked by glutaraldehyde for ophthalmic drug delivery. Carbohydrate Polymers, 2017, 155:208-217. (IF=7.182, JCR:1)

2.Yu Shihui, Tan G, Liu D, et al. Nanostructured lipid carrier (NLC)-based novel hydrogels as potential carriers for nepafenac applied after cataract surgery for the treatment of inflammation: design, characterization and in vitro cellular inhibition and uptake studies[J]. RSC advances, 2017, 7(27): 16668-16677. (IF=3.119, JCR:3)

3.Yu Shihui, Li Q, Li Y, et al. A novel hydrogel with dual temperature and pH responsiveness based on a nanostructured lipid carrier as an ophthalmic delivery system: enhanced trans-corneal permeability and bioavailability of nepafenac[J]. New Journal of Chemistry, 2017, 41(10): 3920-3929. (IF=3.288, JCR:3)

4.Yu Shihui, Wang, Q. M., Wang, X., Liu, D., Zhang, W., Ye, T., ... & Pan, Weisan*. Liposome incorporated Ion sensitive in situ gels for opthalmic delivery of Timolol Maleate. International Journal of Pharmaceutics, 2015, 480(1–2):128-136. (IF=4.845, JCR:2).

5.Yu Shihui, Wang S, Zou P, et al. Inhalable liposomal powder formulations for co-delivery of synergistic ciprofloxacin and colistin against multi-drug resistant gram-negative lung infections[J]. International Journal of Pharmaceutics, 2020, 575: 118915. (IF=4.845，JCR:2, 共第一)

6. Yu Shihui, Yuan H, Chai G, et al. Optimization of inhalable liposomal powder formulations and evaluation of their in vitro drug delivery behavior in Calu-3 human lung epithelial cells[J]. International Journal of Pharmaceutics, 2020: 119570. (IF=4.845, JCR:2)

7. Wang Shaoning, Yu Shihui, Lin, Y., Zou, P., Chai, G., Heidi, H. Y., ... & Zhou, Qi*. Co-Delivery of Ciprofloxacin and Colistin in Liposomal Formulations with Enhanced In Vitro Antimicrobial Activities against Multidrug Resistant Pseudomonas aeruginosa. Pharmaceutical research, 2018, 35(10): 187. (IF=3.896, JCR:3, 共第一)

8. Dandan Liu, Shihui Yu, Z Zhu, et al. Controlled delivery of carvedilol nanosuspension from osmotic pump capsule: in vitro and in vivo evaluation. International Journal of Pharmaceutics, 2014, 475(1–2):496-503. (IF=4.845)

9. Yingna Xue, Shihui Yu, H Wang, et al. Design of a timed and controlled release osmotic pump system of atenolol. Drug Development and Industrial Pharmacy, 2015, 41(6):2877 - 2884. (IF=2.429)

10. Guoxin Tan, Shihui Yu, H Pan, et al. Bioadhesive chitosan-loaded liposomes: a more efficient and higher permeable ocular delivery platform for timolol maleate. International Journal of Biological Macromolecules, 2017, 94, 355-363. (IF=5.162)

11. Guoxin Tan, Shihui Yu, Jinyu Li, Weisan Pan*. Development and characterization of nanostructured lipid carriers based chitosan thermosensitive hydrogel for delivery of dexamethasone. International Journal of Biological Macromolecules, 2017, 103, 941-947. (IF=5.162)

申请专利2项

1.朱志红，潘卫三，曲绪楷，杨星钢，梁静阁，李淑娟，于世慧

盐酸曲美他嗪双层渗透泵控释片及制备方法。中国发明专利：201410013277.8;103735528B.

2.潘卫三，张文骥，孔郡，李雪东，陈奋，于世慧，李静，李三鸣

一种金雀异黄素阳离子纳米脂质载体及其制备方法. 中国发明专利：CN 103271892.

会议论文1篇

1.首届全国药学类研究生学术论坛，Shihui Yu, Guoxin Tan, Dandan Liu, Xinggang Yang*, Weisan Pan*. Nanostructured lipid carrier (NLC)-based novel hydrogels as potential carriers for nepafenac applied after cataract surgery for the treatment of inflammation: design, characterization and in vitro cellular inhibition and uptake studies. （南京，中国，2017年5月）

获奖情况

1.2016-2017学年荣获国家奖学金，一等学业奖学金；

2.2015-2016学年荣获博爱新开源研究生企业奖学金，一等学业奖学金；

3.2014-2015学年荣获卡乐康研究生企业奖学金，一等学业奖学金；

4.2017.02荣获教育部科学技术进步二等奖（第8完成人）